標題: Jan Jun 2014 03 [打印本頁] 作者: uyolkhapr 時間: 2016-3-30 12:27 標題: Jan Jun 2014 03
Newcastle University experts closer to slowing down ageing process
Experts in Tyneside may be a step closer to finding a way to slow down the ageing process.
Newcastle University scientists have identified that damaged protein could be one of the key aspects to premature ageing.
The team found that the condition of key proteins Kamagra Oral Jelly Wiki in the mitochondria the batteries of cells may be used to predict, and eventually treat, premature ageing.
It was established that one way of slowing down the aging process was by restricting diet to reduce the number of calories consumed.
A study with mice identified that by using calorie restriction, a system whereby the cells are deprived of nutrients, rodents were able to live longer than normal.
Thomas Von Zglinicki, professor of cellular gerontology Viagra Sydney Cheap at the Institute for Ageing and Health, Newcastle University, said it was an important breakthrough as Generic Levitra Reviews the study suggested differences in lifespan.
He said: "Free radicals have long been linked with the ageing process. Mitochondria generate the energy required to keep our bodies going but they also generate free radicals.
"How exactly they are involved in ageing is still controversial. Our data shows that quite minor differences can explain large variations in healthy lifespan.
"Essentially what we have found is that the ageing process goes slower than normal in mice that managed to form mitochondrial protein complexes more efficiently, and that we actually could help them to do so."
In a complex state, proteins work together more effectively, while on their own they generate toxic free radicals, which in turn cause cells to age more rapidly.
If a similar mechanism is found in people it could lead to treatments, such as new drugs to improve protein assembly.
A complex of 96 proteins is at the heart of the mitochondrial power station.
Comparing the protein composition, the team found the mitochondria from long lived animals surprisingly had less of these proteins and thus seemed less well suited for energy production than the shorter living mice.
However, further research Viagra Sydney showed that assembly of the protein complex was the key.
If individual components were more scarce, the protein complex was perfect, but became more sloppy if Levitra Vs Viagra more material was around.
This then led to less efficient energy production and more release of oxygen free radicals, toxic by products of mitochondrial metabolism.
Dr Satomi Miwa, joint lead researcher on the team and a specialist on mitochondrial function, said: "These data go a long way to explain how calorie restriction can improve mitochondrial function, extend lifespan and reduce or postpone many age associated diseases."
Professor Thomas von Zglinicki added: "We have shown here that complex assembly efficiency correlates to longevity differences in Kamagra Tablets Australia mice that correspond to one or two decades of healthy life in humans.
"We have also shown that human Viagra Singapore Price cells age faster if we corrupt complex assembly.
"What we now need to do is to see how we can improve the quality of these protein complexes in humans and whether this would extend healthy life."The Chronicle is read by more adults than Kamagra 100mg Oral Jelly Review any other regional newspaper on sale in the area. With 170,115 average issue readers, this reach extends to 366,753 weekly readers that's over 1/4 of adults in the area!
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