Scientists say drug may extend the lifespan of dogs
Matthew Kaeberlein and Daniel Promislow received an unrestricted $200,000 grant from the UW to study Rapamycin's potential effects on the Nike Shoes Online.html longevity of dogs.
Rapamycin is used in combination with other drugs to prevent organ rejection in patients who have received an organ transplant. The drug was approved by the FDA for use in humans in the mid '90s and is now "off patent."
Kaeberlein, who is also is a proud owner of two dogs, has performed his own studies on mice and cites "50 other studies" that indicate Cheap Supra High Tops Rapamycin has improved the longevity of middle aged mice by nearly 40 percent with few side Cheap Nike High Heels Nz effects.
"Knowing that we can do it safely and it's almost certain to work, it Nike Free Run 5.0 Womens just seems obvious to me that this is the next step," said Kaeberlein, an associate professor and molecular biologist at UW.
He want to test Rapamycin on several breeds Genuine Pandora Charms Nz of mid to large Longchamp Online sized dogs that are five to seven years old and study them for a period of five years.
Kaeberlein believes dogs are the next step before any human trials are considered because dogs suffer similar ailments with humans, including heart and kidney disease.
"The real goal is to delay the chronic and degenerate diseases of aging as long as possible, and that's what we see in the mice and that's what we expect to see in dogs," said Kaeberlein, who said he'd gladly offer his own dogs as part of the study.
He won't be involved in deciding which dogs make it into the study. To avoid any conflict of interest, a panel of veterinarians will monitor the study will make those decisions.
Kaeberlein says he's hoping for "citizen scientists" who are also dog owners will join the research project which needs more funding to be successful. They hope to start the nationwide study in the next six months.
"I think that's what most owners want, more quality time with their pet," said Kaeberlein.
Having several breeds/mongrel dogs in my life over the years with one reaching 20 and my current dog at 19 years of age I am against this. Who wants their life or that of their dog extended when you have reached senior years with all its daily medical realities. Better to focus on hips/bones/ bowel and other dog infirmaties that speed up old age in a younger pet. We can put our pet "down" when it is "time." But, humans aren't allowed to do so for another human without legalities. Watching a human or pet in dire unreversible pain is hard to experience. Love your fellow human/pet taking joy in knowing God has already chosen a time to part with you.
I have been without a dog for about 4 years. My last two dogs were purebred Golden Retrievers. Both amazing and wonderful companions. One died at 14 and the last at 12. Both had breed common ailments brought on by a long history of too much interbreeding by professional breeders. I have since done a lot Oakley Nz Queen Street of reading and find that virtually every breed has these kind of issues. So, my easier fix for my next dog will be adopting a mixed breed aka. mutt. Now all I have to do is move from a condo back to a house with a yard. That will make that free dog what, around a $ half mil.
I've had old dogs that have arthritis and in constant pain when they move. I had to make Ray Ban Aviators New Zealand some major decisions of whether to endure the vet bills or put the old dogs down. If they get untreatable health problems, then I do wish for them to endure the pain longer than they need to and would rather have them put to sleep. I even had one that became senile at the end of her life. So, extending a life of a dog may be a nice thing, but if the quality of their life is deteriorating due to health, then if is best to let them go.
As a human, I would probably want the same thing done for me if the roles were reversed.
I don't know how do you keep them from just getting OLD and broken down like they and we get? I know that's what they're trying to determine. We have a very senior dog now and he is trucking right along, happy as can be. We started exercising him, and he's now walking 1.5 miles a day when it's not raining, and it's like he's doing some weird Benjamin Button thing. We are just grateful for the time we have.
We don't like that we lose them, but death is part of life and there's another one waiting to be adopted when they go. In fact, it seems like they send them to us. The right dog in need of a home just sort of materializes.
I love that dog's mouth and nose. It looks like a big cave with a sleeping bag hanging out, waiting for something to crawl in and take a nap.
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